Search for: [Abstract = "Obstructive sleep apnea \(OSA\) caused by diminished patency of the upper airways with a maintenance of the respiratory effort is a \(max 1400 znaków\) common disease, affecting from 2 to 4% of the European population. OSA is characterized by repetitive episodes of apnea and hypopnea during sleep. Untreated OSA increases the risk of cardiovascular diseases, including myocardial infarction or ischemic stroke. The occurrence of chronic episodes of intermitted hypoxia and reoxygenation, together with sleep fragmentation and its regulatory mechanisms during OSA, lead to chronic systemic inflammation, which can accelerate the development of atherosclerosis. Increased blood hematocrit, elevated levels of fibrinogen and increased blood viscosity probably also play an important role in atherothrombosis in OSA patients. The gold standard of severe OSA treatment is the use of the continuous positive airway pressure \(CPAP\). In the mild and moderate forms other therapeutic options are often indicated, including oral appliances. Till today, it has been demonstrated that treatment with oral appliance ameliorates the polisomnographic features of OSA, decreases the subjective symptoms, improves endothelial function and autonomic cardiac modulation as well as diminishes arterial blood pressure. The aim of this study was to assess whether oral appliances influence the inflammatory and hemostatic mar"]

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