Search for: [Abstract = "Objectives To estimate levels of chemokine RANTES and it’s association with endothelial dysfunction in two different groups of patients\: with diabetes at high cardiovascular risk and stable angina undergoing coronaroangiography. Methodology Group I\: level of chemokine RANTES in serum was assessed in 128 consecutive patients at the average age of 56,6 \(from 43 to 72 y.o.\; SEM=0,56\) with diabetes. Brachial flow mediated dilation \(FMD\) and vWillebrandt factor \(vWF\) were used to asses endothelial dysfunction. Measurement of Intima\-media thickness \(IMT\) in carotid arteries was assesed to evaluate patients with and without atherosclerotic plaques. MDA levels were measured to analize RANTES association with oxydative stress. Group II\: level of chemokine RANTES in serum was assessed in 62 consecutive patients at the average age of 59,3 \(from 46 to 78 y.o.\; SEM=0,94\) with stable angina pectoris undergoing coronarography. Number of diseased coronary arteries was analized. More than 50% stenosis was considered as hemodynamically significant. Three or more arteries significantly narrowed were considered as multivessel disease. Patients were qualified to two subgroups \(multivessel disease vs. less severe atherosclerosis ≤2 significantly stenosed arteries\). Risk factors of coronary artery disease and inflamatory marker IL\-18 were analyzed in all patients. Levels of chemokine RANTES"]

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