Search for: [Abstract = "Objective of the study was to determine whether L.rhamnosus strains \(573L\/1\; 573L\/2\; 573L\/3\) enclosed in the preparation Lakcid L®, have an influence on acute diarrhea in children from 2 m. to 6 y. old. Randomized, double\-blind, placebo\-controlled trial was performed. Primary outcome measure was the diarrhea duration. Secondary outcome measures were\: weight gain, no. of stools in consecutive days, duration of parenteral rehydration, diarrhea lasting over 7 days and GI tract colonization by administered strains. 93 patients were enrolled to the study. Children were treated according to ESPGHAN recommendation and additionaly , they received either 1.2  1010 CFU mixture of L. rhamnosus strains or placebo twice daily for 5 consecutive days. Results\: 87\/93 \(93,5%\) patients were analyzed. 46\/87 \(52,9%\) children were in probiotic group and 41\/87 \(47,1%\) were in placebo group. 39\/87 \(44,8%\) had rotaviral infection \(22 recived Lakcid L, 17 recived placebo. Mean duration of diarrhea in the treated group\: 83.6 ± 55.6 h\; in placebo group\: 96 ± 71.5 h \(p=0,36\). In rotavirus infection\: 77.5 ± 35.4 h vs 115 ± 66.9 h \(p=0,03\), respectively. Duration of parenteral rehydration 14.9 ± 13.7 h vs 37.6 ± 32.9 h\; \(p=0,006\). The applied probiotic strains were detected in stool samples of 37\/46 \(80.4%\) children in 5 days and in 19\/46 \(41.3%\) samples in 14 days after initiating the treatment. Conclusions\: Lakcid L administered orally in dose 1,2x1010CFU twice daily for 5 consecutive days has no influence on diarrhea of any etiology but shortens the duration of rotaviral diarrhea in children which is probably related to succsessful gut colonization."]

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