Search for: [Abstract = "Objective\: Vascular endothelial growth factor type C \(VEGF\-C\) is a novel marker for sodium accumulation in the subcutaneous tissue, yet unexplored in humans. Animal studies have shown a significant correlation between excess sodium intake, increased levels of VEGF\-C in the plasma and higher blood pressure. The aim of this thesis was to evaluate the relationship between the level of serum VEGF\-C and blood pressure in the general population, determine the factors influencing VEGF\-C serum levels in population and to assess the impact of the interaction between plasma VEGF\-C and sodium intake on the blood pressure in the general population. Methods\: In this cross\-sectional cohort study, participants were recruited from the general population of the Malopolska Region of Poland, including 109 families, a total of 303 people. With every participant, we performed\: ambulatory blood pressure measurement \(SpaceLabs 90207\), complete blood count, serum concentration of creatinine, uric acid, C\-reactive protein, glucose, electrolytes \(sodium, potassium\), lipid profile, measurement of plasma renin activity, levels of inflammatory markers \(interleukin\-6 and myeloperoxidase\) and plasma VEGF\-C concentration was measured using ELISA kit. Sodium intake and lithium clearance was assessed based on 24\-hour urinary sodium excretion. The measurement of the extracellular fluid volume, total body water and fat mass was conducted using the method of bioelectrical impedance \(Bodystat® Quadscan 4000, Isle of Man, British Isles\). Statistical analyses were performed using SAS \(SAS Institute, Cary, NC\) version 9.3."]

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