Search for: [Abstract = "Obestatin is a peptide derived from the same gene as ghrelin. Obestatin, as a ghrelin, has been originally extracted from rat stomach, and the stomach seems to be a major source of endogenous obestatin. Previous studies have shown that ghrelin exhibits protective and therapeutic effect in the pancreas. Administration of ghrelin inhibits the development of acute pancreatitis and accelerates pancreatic recovery in the course of this disease. Recent study has shown that obestatin promotes survival of isolated human pancreatic cells and β\-cells, as well as improves the generation of functional β\-cells in vitro from mouse pancreatic islet\-derived precursor cells.Aim of the present study was to investigate the influence of obestatin administration on the development and course of cerulein\-induced acute edematous pancreatitis.Methods\: Studies were performed in two separate series on male Wistar rats. In both series of studies, acute pancreatitis was induced by five intraperitoneal injection of cerulein \(given at the dose of 50 μg\/kg\/dose\) with 1\-h intervals between injections.The first series of studies were performed to examine the effect of obestatin administration on the development of acute pancreatitis. Obestatin was given twice \(30 min prior to the first injection of cerulein, and 3 h later\) at the dose of 4, 8 or 16 nmol\/kg\/dose. This series of studies was ended 1 h after the l"]

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