Search for: [Abstract = "Obesity is a chronic disease that affects over 650 million people worldwide. The causes for the development of the disease are increased consumption of fat and carbohydrates, low physical activity and individual genetic predisposition. Only a small percentage of obesity is monogenic. The remaining impact on the development of obesity is considered in the epigenetic regulations as DNA methylation, post\-translational modifications of histones and synthesis of non\-coding microRNAs that cause changes in genes activities. DNA methylation occurs by attaching a methyl group to the fifth carbon of the cytosine in gene promoters and important regulatory sites. DNA methylation is cell and tissue specific, sensitive to environmental influence, and may alter in response to changes in physical activity, caloric restrictions and bariatric surgery. It is postulated that DNA methylation may be the cause of development of obesity and its accompanying complications, but it also arises in response to disease. The assessment of the DNA methylation profile in obese patients' leukocytes, carried out as part of this doctoral dissertation, was associated with high levels of LDL cholesterol and FGF21 in the serum. OBJECTIVES The overall aim of the dissertation was to investigate whether there are epigenetic regulations related to metabolic complications i"]

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