Search for: [Abstract = "Levels of progesterone and 17β\-estradiol during menstrual cycles can be influenced by genetic and environmental factors. The aim of this dissertation was to investigate associations of polymorphisms of genes encoding enzymes involved in reproductive steroid metabolism – CYP17, CYP19, CYP1A1 and CYP1B1 with levels of progesterone and 17β\-estradiol in women of reproductive age. These relationships were also controlled for the confounding effects of other factors related to levels of sex hormones in women – body mass index \(BMI\), percentage of body fat, physical activity, age at menarche and length of the menstrual cycle. One hundred and eighteen healthy women, aged 24 to 36 years, with regular menstrual cycles, and fulfilling other criteria for participation, took part in the study. Hormone levels were measured in daily collected saliva samples for one entire menstrual cycle. Blood samples were used for genotyping, anthropometric measurements were taken and questionnaire interviews were conducted. Results of the study showed that, after controlling for the effects of BMI, percentage body fat or physical activity, there were statistically significant associations between CYP17 and CYP19 genotypes and17β\-estradiol levels. There were direct associations between CYP19 genotypes and luteal progesterone levels, and associations between CYP17, CYP1A1 and CYP1B1 genotype"]

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