Search for: [Abstract = "Investigations within PhD thesis concerned design of new cholinesterases inhibitors as potential drugs in Alzheimer’s disease by applying of molecular modeling techniques. In the theoretical part the issues of Alzheimer’s disease were described. The special attention to cholinesterases as therapeutic targets was paid. Cholinesterases’ structure and inhibitors, used in the therapy of AD, were described. In the experimental part results of molecular modeling, joined with design of new cholinesterases inhibitors, were described. In the first step library of own compounds was prepared, basing on substances which were synthesized in the Department of Physicochemical Drug Analysis UJ and also planned for synthesis. A series of carbamates was obtained. Its activity was tested by Ellman’s method. Electrophoretically mediated microanalysis was evaluated as rapid method for determination of activity. Physicochemical and pharmacokinetic properties were predicted and structure \- activity relationships were found. Interactions between compounds and AChE or BuChE were described. New cholinesterases inhibitors were designed. Compounds from ZINC database were under virtual screening with pharmacophores and docking procedure."]

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