Szukana fraza: [Abstrakt = "Introduction. Skin cancers are the most common cancers, and of these, the most aggressive type is malignant melanoma. Due to its rapid growth rate, dynamic development and frequent metastases, it is the most difficult to treat and therefore has the worst prognosis and the highest mortality rate. According to the latest epidemiological data, the incidence of melanoma is rapidly increasing at an alarming rate compared to any other type of cancer. The reasons for the extreme increase are only partially understood. Skin melanoma is a cancer with a high cure rate when the disease is limited to the skin. Detection of melanoma at an early stage, better understanding of the risk factors that increase its occurrence and their prevention are a priority to reduce mortality. Currently, the concept of melanoma oncogenesis is considered to be a multifactorial process involving genetic, epigenetic and environmental factors. Identification of genetic, epigenetic and environmental factors affecting the formation of melanoma may lead to improved prevention and diagnosis of melanoma, as well as early diagnosis of patients with an increased risk of progression and better oncological results. Aim of the study. The aim of this doctoral dissertation was a comprehensive analysis of the pathogenesis of malignant melanoma of the skin, including the identification of environmen"]

Wyników: 1