Search for: [Abstract = "Introduction. Olanzapine is an atypical antipsychotic of thienobenzodiazepine group, which is used in the treatment of schizophrenia, maniacal phase of bipolar disorder and other psychiatric diseases. Its multidirectional activity as an antagonist of D1\-4, 5\-HT2A, 5\-HT1C, H1, α1 and M1\-5 receptors, apart its therapeutic properties, results in different side effects and the rich symptomatology in cases of acute poisoning. The growing number of olanzapine poisonings requires supporting of toxicological diagnostics by the quantitative measurement of olanzapine serum concentration. Aims of the study. In the course of acute olanzapine poisoning\: \(1\) to evaluate the frequency and the intensity of clinical symptoms\; \(2\) to study the drug toxicokinetics\; \(3\) to examine relations among olanzapine serum concentration or the other toxicokinetic parameters and the intensity of selective clinical symptoms, physiological parameters and laboratory abnormalities\; \(4\) to estimate the impact of some demographic, individual and iatrogenic factors on olanzapine serum concentration. Material. 26 adult patients \(11 men and 13 women\) hospitalized in the Toxicology Clinic in Krakow and the 1st Clinic of Internal Diseases and Acute Poisonings in Gdansk since 2005 to 2008 because of acute olanzapine poisoning. Methods. Data about the poisoning clinical course were extracted from medical records. The"]

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