Search for: [Abstract = "Introduction Several previous studies have shown that obestatin exhibits protective and healing\-promoting effects in some organs including the stomach, the kidneys, and the brain. In the pancreas, pretreatment with obestatin inhibits the development of cerulein\-induced acute pancreatitis \(CIP\), and promotes survival of pancreatic beta cells and human islets. However, no studies investigated the effect of obestatin administration in the course of experimental acute ischemia\/reperfusion \(I\/R\) \-induced pancreatitis in experimental models. Moreover, protective effect of pretreatment with obestatin in the cerulein\-induced AP has been proved, however, no studies have investigated the consequences of this peptide administration on the course of cerulein\-induced AP. Aim of the study The aim of the first series of the study was to check the universality of protective effect of obestatin in the pancreas. For this reason we investigated the influence of obestatin administration on the development of ischemia\/reperfusion\-induced pancreatitis. The aim of the second series of the study was to evaluate the impact of obestatin therapy in the course of ischemia\/reperfusion\-induced pancreatitis. The aim of the third series of studies was to determine the impact of obestatin therapy on the course of cerulein\-induced pancreatitis. Methods In the first series of the study AP was induced by pancreat"]

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