Search for: [Abstract = "Introduction Risk of cutaneous melanoma and basal cell carcinoma is very closely connected with sun exposure and skin phototype. Patients with fair skin complexion, who hardly get a suntan, easily sunburn and additionally are exposed to high doses of UV radiation, have predisposition to these skin cancers. The risk of having melanoma or basal cell carcinoma is a complex interplay between personal predisposition and environmental factors. Melanocortin\-1 receptor gene may play a role in a skin cancer development. Human pigmentation depends on eumelanin and pheomelanin ratio. The type of the , produced melanin is connected to MC1R status. The frequency of MC1R polymorphisms varies in different populations and together with pigment phenotype determines personal skin cancer risk. ASIP \(Agouti Signaling Protein\) gene is the second gene that potentially plays a role in the melanogenesis. In mice ASIP protein binded to MC1 R antagonizes MSH activation of the receptor, which results in eumelanin underproduction and pheomelanin prevalence. Two ASIP variants have been identified so far, which differ in one nucleotide position, 8818A>G mutation probably leads to excessive transcript degradation and eumelanin production. This mutation may be responsible for masking of the effects of MC1 R gene variants predisposing to fair phenotype. Aim of the study The main purpose of th"]

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