Search for: [Abstract = "Introduction Inflammatory bowel disease \(IBD\) is an umbrella term for chronic inflammatory diseases of the gastrointestinal tract, including ulcerative colitis \(UC\) and Crohn disease \(CD\). The etiopathogenesis of IBD is complex and remains unclear. The mutual influence of genetic and immune factors as well as the disruption of the intestinal microbiota \(dysbiosis\) and its metabolites, particularly short\-chain fatty acids \(SCFAs\), are considered in the development of these diseases. SCFAs are the main products of fiber fermentation by large intestinal microbiota. The main SCFAs found in the intestines are butyric, acetic, and propionic acids. They have numerous benefits for the human body, such as anti\-inflammatory effects and improved integrity and function of the intestinal barrier. The SCFA profile has not been fully explored in patients with IBD so far. Moreover, there are no data on factors that may affect SCFA levels, such as diet or medications. Chronic inflammation of the intestinal mucosa is associated with impaired intestinal barrier, its increased permeability, and increased antigens presentation on the surface of host’s immune cells. At the same time, an increased expression of inflammatory cytokines, such as tumor necrosis factor α \(TNF\-α\) and interleukin 6 \(IL\-6\), is observed. Moreover, there are disturbances in the expression of intercellular junction proteins,"]

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