Search for: [Abstract = "Introduction\: Peripheral artery disease \(PAD\) affects about 3\-10% of the global population, and in Western European countries 6\-18% of residents over 55 years old \[1\-5\] are ill. Atherosclerosis is influenced by many risk factors associated with abnormal lifestyles, which are the main cause of vascular endothelial dysfunction. In the course of PAD, chronic pain \(CP\) develops, which affects the treatment process and patients' quality of life. Research to date and available literature indicate a significant role of the inflammatory response in the etiopathogenesis of atherosclerosis and CP, including pro\-and anti\-inflammatory cytokines and substance P \(SP\) \[6\-10\]. The feeling of pain and stress accompanying the disease determine the patient's individual coping strategies for CP. The activity of inflammatory markers present in the course of inflammatory disease determines how to manage pain\/stress \[11, 12\]. Aim of the study\: The main goal of the study is to determine the role of inflammatory and SP markers in the severity of CP and ischemia in patients with PAD in the light of strategies for coping with pain. Material and methods\: Cross\-sectional observational study with a control group. A group of patients experiencing CP in the course of PAD \(study group\), compared to a group of people with atherosclerosis, of other arteries including peripheral arteries, not experiencing pai"]

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