Search for: [Abstract = "Introduction\: One of possible mechanisms leading to the development of chronic diabetes complications is endothelial dysfunction \(ED\). Aim\: To asses ED in patients with DM 2 and to assess the relationship between ED and diabetic retinopathy. Material\: 182 patients with DM 2 with mean age 56,3 yrs. The control group included 43 healthy volunteers. Methods\: We assesed endothelial function by flow\-mediated dilatation \(FMD\) and by assessment of von Willebrand factor \(vWf\) and s\-ICAM .Retinopathy was assessd using fundus photography\; intima\-media thickness of carotid artery by usg. Statistical analysis included multiple regression analysis. Results\: Diabetic retinopathy was found in 39,0% of patients. Mean IMT was significantly higher and FMD lower in DM 2 patients than in control group \(respectively 0,83 mm vs. 0,66 mm, p<0,00005 and 9,0% vs. 11,4%, p=0,0165\). In patients with diabetic retinopathy IMT was higher than in patients without retinopathy \(0,87 mm vs 0,79 mm, p=0,0001\), while FMD was lower \(8,38% vs 10,45%, p=0,0023\). In multiple regression analysis age, insulin therapy, hypertension and retinopathy were independenet predictors for IMT value, while retinopathy and HbA1c as well as total cholesterol level for FMD. Conclusions\: DM 2 patients are characterized by common occurence of ED and increased intima\-media thickness. Incidence of IMT and FMD abnormalities is higher in"]

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