Search for: [Abstract = "Introduction\: Aspirin\-induced urticaria \(AIU\) is along with aspirin\-induced asthma \(AIA\), one of the most frequent types of aspirin hypersensivity reactions. The role of cysteinyl leukotrienes and prostaglandin D2 \(PGD2\) in the aspirin sensitivity reaction was the subject of research in both AIU and AIA. Prostaglandin E2 \(PGE2\) seems to be of importance in the pathogenesis of aspirin hypersensivity. However, the results of its role in AIA are diverse. Objective\: In the present thesis a clinical course of AIU was analyzed during four years of clinical observation and taken twice\: oral aspirin challenge tests and laboratory tests \(LTE4 i PGD2\-M in urine\). The point of interest was also to find if aspirin has an impact on systemic PGE2 production in AIU. Methods\: The study was performed in 22 AIU patients. The study was divided into two parts. In the first part\: on the basis of control appointments and questionnaires the beginnings of acetyl salicylic acid \(ASA\) hypersensivity was analyzed and clinical observation of AIU \(2002\-2006\) was conducted. In the second part\: \(in 2006\) an aspirin oral challenge test was performed once again. Urine for LTE4, PGD2 and PGE2 metabolites was collected at baseline\; at the time of the end of the challenge and 2 and 4 hrs later. Moreover, base levels of urinary PGE2 \- metabolite was evaluated in 22 healthy volunteers. For the assessment of the sev"]

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