Search for: [Abstract = "Inflammatory bowel diseases are chronic diseases of gastrointestinal tract, which include Crohn’s disease and ulcerative colitis. About 15% of cases are difficult to diagnose using clinical, radiological and histopatological methods. In this study three neutrophillic proteins \(leukocyte elastase, lactoferrin, calprotectin\), intestinal fatty acid binding protein and neopterin were evaluated as biomarkers used in the diagnosis and the assessment of clinical activity of Crohn’s disease and ulcerative colitis. Additionally a set of antibodies was evaluated. The study included 27 patients with Crohn's disease, 33 patients with ulcerative colitis and 20 healthy controls. Plasma concentrations of the studied proteins and the presence of antibodies were compared between the studied groups.. Plasma calprotectin, lactoferrin, elastase, I\-FABP and neopterin concentrations were measured using ELISA. ANCA, ASCA, LFS, GAB, CUZD1 and GP2 antibodies were detected using indirect immunofluorescence. In patients with both inflammatory bowel diseases higher plasma concentrations of leukocyte elastase, calprotectin and lactoferin than in control group were found. Diagnostic characteristics of these tests indicate their usefulness in the IBD diagnosis. Significantly higher elastase\/NEU and lactoferrin\/NEU ratios in patients with ulcerative colitis as compared to patients with Crohn's disease can be"]
