Search for: [Abstract = "In the theoretical part of this dissertation were presented the physiological role of 5\-HT1A, 5\-HT2A and 5\-HT7 receptors and examples of their ligands. The known structure affinityrelationships and the published pharmacological models of the ligand\-receptor interactions were also discussed. The results ofthe previous research of serotonin receptor ligands in the group of methylxanthines’ derivatives and the structure\-activity relationshipin this group of compounds were presented. In the practical part the synthesis of 7\-arylpiperazyinylalkyl derivatives of theophylline with differently substituted 8\-aminogroup was presented. The structure of the obtained compounds was confirmed with elemental analysis, MS and 1H\-NMR. The purity of these compounds was analyzed with UPLC. The final compounds were checked for their serotonin receptor affinity, what led to identification of compounds, which are 5\-HT1A, 5\-HT2A and 5\-HT7 receptor ligands and one mixed ligand of 5\-HT1A and 5\-HT7 receptors. Basing on the results the structure\-activity relationship in this group of compound was analyzed."]

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