Search for: [Abstract = "In the control group no changes of all parameters studied were observed after 6 months. In the OSA group the decrease of IL\-1 ß concentrations after the first 3 months from 0.35 pg\/ml to 0.19 pg\/ml \(p<0.001\) was noted. In the following 3 months this parameter did not change \(p=0.12\), similarly to the control group \(p=0.61\). After the first 3 months of oral appliance treatment, a 43% decrease of IL\-10 concentrations close to the level of statistical significance was found \(p=0.06\) without further reduction after the next 3 months \(p=0.66\). The concentration of PAI\-1 during a 6\-month treatment with oral appliance was reduced to 19.89 ng\/ml \(29.6 %\) \(p=0.008\). Interestingly, the concentration of TAFIa also decreased in the OSA group during oral appliance treatment from 81.23 pmol\/l to 43.43 after 6 months \(p=0.001\), which accounts for 50.5% of the initial concentration, and this fall was substantial already after the first 3 months \(p=0.029\). A significant correlation between IL\-1ß and PAI\-1 concentrations at the 3 time points was found. Similarly there was an association of TAFIa concentration and AHI as well as the oxygen saturation lower than 90%. Other markers of inflammation, including CRP, and those of hemostasis, including thrombin generation, remained unaltered during 6 months of oral appliance use. Summarizing, this study confirms the effectiveness of treatment with oral appliances in the moderate OSA, which is corraborated by a marked improvement of the polisomnographic parameters. Importantly, for the first time it has been shown that the treatment with oral appliances in moderate OSA patients decreases the concentrations of IL\-1 ß and IL\-10 and produces the profibrinolytic effect, which demonstrates novel, as yet unknown effects of the oral appliance treatment. The original observation is also the presence of increased TAFIa concentrations in the moderate OSA, which were reduced after oral appliance treatment. These observations increase our knowledge about the mechanisms which may favuor the development of atherosclerosis and thrombosis in moderate OSA and that these mechanisms can be effectively modified by oral appliance treatment."]

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