Search for: [Abstract = "In summary, in the neurochemical state ‒ animal models of depression showed multidirectional changes within the endocannabinoid system \(i.e. receptors and endocannabinoids levels evoked by altered expression of metabolizing enzymes\), and these changes seem to be associated with the particular brain structure and factor inducing this disease. A common feature for both models was a reduction of the anandamide levels in the dorsal striatum, which may be associated with anhedonia, a symptom of depression, while all chronically administered antidepressant drugs\/compounds caused an increase in the levels of anandamide in this brain structure. Antidepressant drugs\/compounds evoked an increase of anandamide levels in the hippocampus and also an increase of 2\-AG levels in the dorsal striatum. 10\-day washout period kept changes following repeated treatment with ESC, while changes after other drugs\/compounds seem to be short\-lived. The changes in the endocannabinoids levels were in most cases dependent on both types of CB receptors. Neurochemical studies on CB receptors showed different changes in the density\/expression of CB receptors in rat brain, which seem to be related to brain structure and\/or properties of a drug\/compound.Study in this doctoral thesis contributed to explore the mechanisms related to depression and the mechanisms of action of antidepressant drugs\/compounds with particular focus on components of endocannabinoid system. We hope, that the obtained findings will show new directions in studies on depression as a more comprehensive understanding of the enodocannabinoid system with its cellular signaling targets that subserve this brain disorder."]

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