Search for: [Abstract = "In males below 50 years of age CPI value in proximal colon was significantly higher than in females of the same age. The presented results show a dominant role of classical carcinogenesis pathway in malignant transformation in the study group. Alternative pathway \(transformation sequence\: hyperplastic polyp \- serrated polyp\) dominate in proximal colon. Adenomatous polyps are the most commonly found in distal colon. Because the highest grade of dysplasia was found in distal colon and concerned both adenomatous and serrated polyps, distal part of large intestine seems to be very susceptible to intensive progression of precancerous lesions. Both carcinogenesis pathways, related to both classical adenomas and sequential polyps \(hyperplastic polyp \- serrated polyp\) were more often found in males than in females. The alternative carcinogenesis pathway is more often observed in males with no relation to age. On the other hand, adenomatous polyps, because of their pathomorphological structure, are more dangerous to younger men, whereas in elderly patients \(over 70 years of age\) may dominate in women. In patients up to 50 years of age the risk of all polyps' type development is highest in rectum, while in older patients \- in distal colon for adenomatous polyps and with proximal colon for serrated polyps. The above data shed new light on the need to perform additional studies on the selection of patients to endoscopic screening of precancerous lesions in colon. We suggest that males should be screened earlier than females, whereas the maximum age limit should be increased. Canceration potential index \(CPI\) reflects the trends indicating localization, number and pathomorphological features of polyps in various age groups and both sexes. Hence, it can become a useful tool in epidemiologic population studies of colon cancer."]

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