Search for: [Abstract = "INTRODUCTION\: Psoriasis is a common chronic skin disease. In recent years,research has shown the association of dermatosis with numerous accompanyingdiseases, most often with cardiovascular diseases and metabolic syndrome,determining psoriasis as a predisposing factor.OBJECTIVE\: The aim of this dissertation was to evaluate the epidemiology ofpatients with psoriasis and psoriatic arthritis and to study the levels of TNF\-α, IL\-12,IL\-23 and IL\-17 in patients’ blood in correlation with individual components of themetabolic syndrome.MATERIAL AND METHODS\: A retrospective study evaluated data from 3,331hospitalizations and 1,537 outpatient cards of patients with psoriasis. For the studyof cytokines 60 patients with severe psoriasis were included. Control groups were\:15 subjects diagnosed with metabolic syndrome and 15 healthy voluntary subjects.The concentrations of IL\-12, IL\-17, IL\-23 and TNF\-α in serum were determined.RESULTS\: The level of the studied cytokines\: IL\-23 and TNF\-α was higher inpatients diagnosed with psoriasis in comparison to the control group. Higher levelsof IL\-17 were observed in patients with metabolic syndrome associated withpsoriasis. The level of cytokines was also assessed in relation to the presence ofspecific co\-morbidities that are components of the metabolic syndrome. The level ofIL\-17 was higher in the group of patients diagnosed with diabetes mellitus anddislipidemia. In the study, a higher level of IL\-17 and IL\-23 was also shown, inpatients with psoriatic arthritis in comparison to patients with normal psoriasis.CONCLUSIONS\: It seems very important to study immunologic mechanismsresponsible for the presence of psoriasis to personalize the therapy and optimize theeffect of action on the basic disease and on concomitant disorders.\*"]

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