Search for: [Abstract = "INTRODUCTION\: Microsatellite\-unstable tumors can be divided into two distinct phenotypes\: MSI\- high \(MSI\-H\) and MSI\-low \(MSI\-L\). About 15% of colorectal cancers exhibit MSI\-H. Such types are usually right\-sided, have a mucinous histology, poor differentiation, less frequency of metastasis and better prognosis. Clinicopathological features of MSI\-L cancers are not well defined and its significance remains controversial. However, recent studies support that MSI\-L may form a separate entity differing both from MSI\-H and MSS tumors. MATERIAL\/METHODS\: A total of 163 cases with colorectal cancers were assessed for MSI status. Three groups \- MSS \(n=133\), MSI\-L \(n=15\), MSI\-H \(n=15\) \- were compared with respect to stage disease progression, features of angioinvasion and histological grade. Immunohistochemistry of Bcl\-2, Cdx2, Ki\-67, MLH1, MSH2, MSH6, pl 6 and p53 was analyzed on 108 cases of the disease. RESULTS\: In comparison to MSS cancers, the MSI\-L had larger tumor size, mucinous histology and weak expression of MSH6. They had a higher p53 LOH number and were almost only left\-sided contrasting with MSI\-H and MSS tumors. More frequent metastasis and higher TNM stage as compared with MSI\-H tumors indicates for peculiar, worse pathologic behavior of MSI\-L tumors The MSI\-H cancers were significantly larger, more frequently right\-sided, poorly differentiated and had mucinous histolog"]

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