Search for: [Abstract = "INTRODUCTION\: Asthma is a chronic and heterogeneous airway disease characterized by variable respiratory symptoms, including shortness of breath, wheeze, cough, and chest tightness. These clinical features result from reversible airflow limitation related to chronic airway inflammation, bronchial hyperresponsiveness and remodeling. There is growing evidence of increased venous thromboembolism risk in asthma patients. Furthermore, it has been shown that asthma is related to the unfavorably altered thrombin generation profile and extended clot lysis time, indicating a hypercoagulable state of circulating blood in those patients. In addition, there is evidence of a local prothrombotic state in the bronchoalveolar space. Accelerated development of atherosclerosis has been demonstrated in several chronic inflammatory diseases. For example, in asthma research, abnormal brachial artery flowmediated dilatation \(FMD\) and elevated pulse wave velocity \(PWV\) suggest endothelial dysfunction while increased intima\-media thickness of the common carotid artery \(CIMT\) likely points to a higher cardiovascular risk. In addition, most studies on cardiovascular disease epidemiology indicate an enhanced risk of coronary artery disease or stroke in asthma. However, understanding of mechanisms linking asthma pathology with increased thromboembolic and cardiovascular risk is limited."]

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