Search for: [Abstract = "Hypoplastic left heart syndrome \(HLHS\) is the most common congenital single\-ventricle\-type heart defect and the most common cause of heart\-associated death in pediatric population. The Norwood procedure is the first stage of HLHS treatment, associated with a significant risk of death. The objective of the thesis is a prospective evaluation of the association between survival rates, hemodynamic and biochemical parameters, therapeutic modality and perioperative serum endothelin\-1 concentration in newborns with hypoplastic left heart syndrome treated employing the Norwood procedure. The investigation included 30 neonates with hypoplastic left heart syndrome \(investigated group\) subjected to the Norwood procedure in cardiopulmonary bypass and deep hypothermia. The prospective analysis concentrated on dynamic changes of serum Et\-1 concentration levels in arterial blood. The measurements were performed preoperatively, two times in the course of cardiopulmonary bypass, and six times in the postoperative period. The results were compared with Et\-1 values obtained from neonates with transposition of the great arteries \(the controls\). The mean peak concentration value was noted 8 hours postoperatively, both in the investigated group and in the controls. The mean increase of Et\-1 concentration between hour 2 and hour 8 postoperatively amounted to 148 % in patients with HLHS and only to"]

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