Search for: [Abstract = "Hereditary angioedema \(HAE\) due to Cl\-inhibitor \(Cl\-INH\) deficiency is a rare hereditary disease characterized by recurrent subcutaneous or submucosal angioedema due to uncontrolled bradykinin production caused by Cl\-INH dysfunction. Submucosal gastrointestinal swellings provoking abdominal attacks are common and mimie acute abdomen, thus constituting a diagnostic challenge. We aimed to investigate the difficulties in diagnosing abdominal attacks in patients with Cl\-INH\-HAE and to assess the diagnostic value of medical history, the course of the attack, abdominal imaging, and treatment efficacy. The retrospective analysis of diagnostic problems and treatment complications of abdominal attacks in 274 patients with Cl\-INH\-HAE were performed. The value of history, laboratory findings, prodromal symptoms and course of attacks and imaging were assessed. Abdominal attacks were confirmed in 274 of the 322 patients \(85%\; 190 women and 84 men\; age, 4\-70 years\). In 49% of cases, the abdominal attack was the first and the only symptom for years. The simultaneous presence of marginal 'e rythema \(45% of cases\), subcutaneous edema \(30%\), and pharyngo\-laryngeal edema \(10%\) facilitated the diagnosis of an abdominal attack due to Cl\-INHlHAE. Abdominal attacks manifested with recurrent acute abdominal symptoms lasting 2 to 5 days. The disease course was characterized by the p"]

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