Search for: [Abstract = "Heart Failure development may be a direct effect of pathological changes in the heart structure or cardiac function or may be an indirect effect of systemic pathological processes that influence the heart and lead to cardiac remodelling with the subsequent development of the heart failure. In both cases there is a progressive impairment of systolic and diastolic cardiac function and activation of mechanisms that allow the heart to adapt for pathological condition and maintain its function preserved as long as possible. Slowly progressive changes in the cardiac function at early stages of the heart failure are difficult to assess in patients due to lack of symptoms. Detailed studies on the heart failure and its mechanisms are possible however with the use of murine models of various pathologies. The aim of this work was to develop a dobutamine stress test protocol for cardiac magnetic resonance imaging \(MRI\) in mice in vivo and its application to the characterization of two different murine models of heart failure\: Tgαq\*44 mice that develop dilated cardiomyopathy and apoE\/LDLR\-\/\- mice at the advanced stage of atherosclerosis when fed standard \(apoE\/LDLR\-\/\-S\) or Low Carbohydrate High Protein diet \(apoE\/LDLR\-\/\-LCHP\)."]

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