Search for: [Abstract = "Having summed the number of points in the Fazekas scale granted during the assessment of periventricular and deep structures' lesions, 60 patients received 0 points \(23,4%\), 55 patients received 1 point \(21,5%\), 43 patients received 2 points \(16,8%\), 37 patients received 3 points \(14,5%\), 24 patients received 4 points \(9,4%\), 11 patients received 5 points \(4,3%\) and 26 patients received 6 points \(10,1%\). The analysis of the demographic, biochemical and clinical data indicated that the patients with advanced leukoaraiosis \(at least 3 points in the Fazekas scale\) were older, suffered more often from arterial hypertension, diabetes and ischaemic heart disease, and had a higher level of cholesterol, fibrinogen and blood glucose than the others. Linear regression analysis based on the assumption that the Fazekas scale was treated as an infinitely variable proved that an old age and arterial hypertension are independent leukoaraiosis factors. Logistic regression analysis based on the assumption that the Fazekas scale was treated as a dichotomous variable \(at least 3 points vs. less than 3 points\) showed that an old age, arterial hypertension and fibrinogen are independent factors of advanced leukoaraiosis. No correlation between the number of points in the Fazekas scale and the number of points in ASPECTS \(r=0,06, p=n.s.\) was found.Linear regression analysis based on the assumption that both the modified Rankin scale and the Fazekas scale were treated as infinitely variables indicated that arterial hypertension and an advanced neurological deficit assessed by the NIHSS at the moment of falling ill are factors to determine a degree of disability graded according to the modified Rankin scale at a discharge. Linear regression analysis based on the assumption that the modified Rankin scale was treated as an infinitely variable and that the Fazekas scale was treated as a dichotomous variable proved that arterial hypertension, diabetes, a number of white cells and an advanced neurological deficit assessed by the NIHSS at the moment of falling ill are factors to determine a degree of disability graded according to the modified Rankin scale at a discharge. The testing of factors determining a degree of a neurological deficit at a discharge based on the assumption that the modified Rankin scale was analysed as a dichotomous variable did not reveal any factors to determine an early prognosis. Leukoaraiosis did not transpire to be a factor determining an early prognosis in any of the above\-mentioned models.The Kaplan–Meier analysis showed that patients with no signs of leukoaraiosis \(0 points in the Fazekas scale\) or in whom its extent is relatively small \(1\-2 points\) have a considerably higher long\-term survival rate than those who suffer from advanced leukoaraiosis. An estimated survival in the first group amounts to 83,4 months, whereas in the second group it is 68,9 months. This difference is statistically significant \(p=0,015\). An univariate analysis indicated that arterial hypertension \(HR=3,77\; 95%CI\:1,15\-12,35\; p=0,03\) and advanced leukoaraiosis \(HR=2,71\; 95%CI\:1,34\-5,50\; p<0,01 \) are death risk factors. A multivariate analysis stated that only advanced leukoaraiosis was an independent death factor \(HR=2,13\; 95%CI\:1,02\-4,45\; p=0,04\).Leukoaraiosis in an acute stroke phase occurs in approximately 80% of patients and in half of the cases it is very extensive. An old age and arterial hypertension are risk factors of advanced leukoaraiosis in an acute stroke phase. The intensity of leukoaraiosis diagnosed in an acute stroke phase does not correlate with a size of an ischaemic focus. Leukoaraiosis is not an independent factor to determine a short\-term prognosis evaluated by means of the modified Rankin scale. The most significant factor responsible for a short\-term prognosis is a neurological deficit at the moment of falling ill. Leukoaraiosis is an independent factor to determine a long\-term postictal mortality."]

Number of results: 0