Search for: [Abstract = "GSTP1\*B homozygotes has been higher in the ALL group as well, however the difference has not attained statistical significance. These findings suggest that GSTP1\*B polymorphism may influence the risk of childhood ALL in Polish population, however, further evaluation is necessary. The frequency of NQO1\*2\(609C>T\) and NQO1\*3\(465C>T\) genetic polymorphisms in NAD\(P\)H\:quinone oxidoreductase1 gene did not differ between cases and individuals from general Polish population and revealed no association with ALL. Further experiments have investigated the effect of 677C<T genetic polymorphism of MTHFR gene. Observed frequency of 677T allele as well as 677TT genotype has been higher in the cases corresponding to the controls. Data has revealed that individual homozygous for 677C>T genetic polymorphism had 4\-fold increased risk of ALL \(p=0,0006\;OR=4,09\). This results suggest that 677TT genotype is strongly associated with childhood ALL in Polish population.Results of the present study revealed that the distribution of all polymorphic alleles has not differed among separated macro regions of Poland. It seems to be of big significance to continue molecular epidemiological studies investigating the role of polymorphic variants as possible risk factors for cancer development."]

Number of results: 1