Search for: [Abstract = "GF21. Increased expression of hsa\-miR\-875\-5p and decreased expression of hsa\-miR\-133a\-3p, hsa\-miR185\-5p and hsa\-miR\-200c\-3p were found in the group with high serum FGF21. The detected regulations were associated with high levels of FGF21, VEGF and low levels of adiponectin in the serum. CONCLUSIONS 1. A specific DNA methylation profile has been demonstrated in peripheral blood leukocytes associated with high levels of LDL cholesterol in obese individuals. 2. The presented DNA methylation pattern were in genes related to lipid metabolism. 3. We showed novel epigenetically regulated genes\: ABCG4, ANGPTL4, AP2A2, AP2M1, AP2S1, CLTC, FGF19, FGF1R, HDLBP, LIPA, LMF1, LRP5, LSR, NR1H2 and ZDHHC8 and associated with high serum LDL cholesterol. 4. We demonstrated the metabolic profile associated with high level of FGF21 in the studied group of obese patients. 5. The DNA methylation profile associated with high levels of FGF21 in obese subjects were presented in peripheral blood leukocytes. 6. Altered expression of four miRNAs was demonstrated\: decreased for hsa\-miR\-133a\-3p, hsa\-miR\-185\-5p and hsamiR\-200c\-3p and increased for hsa\-miR\-875\-5p in peripheral blood leukocytes in obese subjects with high serum levels of FGF21. These findings may have a potential clinical significance as it has been shown that there is a regulation of epigeneti"]

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