Search for: [Abstract = "For a number of drugs their concentration in the site of action \(the biophase\), determines their therapeutical efficacy. However, in the case of hard tissues owing to their poor and pharmacokinetic properties of a drug, most drugs when administered systemically rarely achieve sufficiently high concentrations in situ. Direct drug delivery into the site of action is an alternative administration route which is an example of targeted drug delivery aiming at assuring optimal drug tissue concentration and at the same time maintaining very low systemic concentration. Biocomposites based on calcium phosphates, and in particular hydroxyapatite ceramics, rank high amongst modem ceramic implants used as bone fillers after removal of defect or dead osseous tissue and may be drug\-loaded.The aim of this work was to investigate the kinetics of in vitro and in vivo release of pentoxifylline and ciprofloxacin as model drugs from hydroxyapatite cements of various microstructure and prepared according to different technological procedures, formulated in tablets or hollow cylinders. The goal of the in vitro study was to assess whether the type of biomaterial used, physicochemical properties of a drug and the release medium influenced the drug release mechanism and profile. In vivo test was aimed to determine the serum drug concentration profile after its administration as a drug\-loaded implant an"]

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