Search for: [Abstract = "First part examined several adaptive changes after repeated zinc treatment in rodent brains using radioreceptor methods. In glutamatergic system adaptive changes \(reduction in glycine affinity to glycine site of the NMDA receptor complex\) in rat cortex were shown. Multiple zinc administration had no effect on the density\/affinity of mGluR5 receptors. In serotoninergic system 5\-HT1A \"up\"\- regulation \(in hippocampus\) and 5\-HT2 \"up\"\- regulation \(in cerebral cortex\) were observed. The results of our studies also shown a \"B\-down\" and \"a1\- up\"\- regulation in the mouse cerebral cortex. No changes were shown in a2\- adrenoceptors. Adaptive changes in NMDA, 5\-HT1A, B\- and a1\-adrenergic receptors caused by chronic zinc administration are similar to these alterations induced by conventional antidepressant drugs. On the other hand, adaptation in 5\-HT2A receptors, is similar to changes induced by electroconvulsive shocks, one of the most effective treatment of depression. In the second part forced swim test was used to estimate the involvement of glutamatergic and serotonergic systems in antidepressant zinc action. Results demonstrated that antidepressant zinc activity is dependent on NMDA, AMPA, 5\-HT1A and 5\-HT2A\/C receptor's activity. Results presented in this dissertation indicate some similarities in the mechanisms of action of zinc and classic antidepressant drugs that"]
