Search for: [Abstract = "Etiology of chronic venous disease \(CVD\), also known as chronic venous insufficiency \(CVI\), is related to leukocyte trapping. Leukocyte trapping relies on white cells trapping to vessel walls, their activation and translocation outside the vessel, and what results in increased blood viscosity and elevated blood flow resistance. These symptoms are manifested by increased endothelial cells permeability and escape of fluids, circumvascular oedema and capillary stenosis. Release of reactive oxygen species \(ROS\) in trapped white cells is observed. It is possible to indirectly determine the effects of ROS in cells or tissues by measuring activity of superoxide dismutase \(SOD\) and glutathione peroxidase \(GPx\). SOD and GPx directly inhibit generation of free radicals and compounds that were produced in a process of oxidation from ROS, such as malonyl dialdehyde \(MDA\). Determination of oxidative stress could be obtained by comparison of measurement results from various markers. The aim of the studies was to establish functions of free radicals in an etiology of venous changes on the level of venous vessels. The following material was used for studies\: peripheral blood, blood stasis in varicose veins, and fragments of sufficient or insufficient venous system and varices from 31 sick persons with diagnosed chronic venous disease in 2 and 3 degree, according t"]
