Search for: [Abstract = "Ethanol is oxidized to acetaldehyde by alcohol dehydrogenase \(ADH\) and this is the main pathway of alcohol oxidizing in social drinkers. Microsomal Ethanol Oxidizing System \(MEOS\) is induced in ethanol addicted individuals and plays the important additional role in ethanol oxidation in this group. The aldehyde dehydrogenase \(AlDH\), enzyme oxidizing acetaldehyde to acetic acid, activity does not get changed. This may lead to acetaldehyde cumulation in alcoholic individuals. The aim of the study was to define the usefulness of acetaldehyde concentration measurement in the blood as the marker of alcohol addiction. 53 alcohol addicted and acutely poisoned patients \(males\) participated in the study. The control group was social drinkers, 43 males, accidentally poisoned with ethanol. Alcohol addiction was diagnosed according to ICD\-10 criteria. On admission to the hospital patient’s history was taken and physical examination was performed. Additionally ECG examination was carried out. Blood samples for biochemical analysis \(K, Na, glucose, bilirubine, AST, ALT, GGT, CPK, urea, creatinine, iron, protrombin, Ht, Hb, RBC, WBC, Plt\) were taken on admission. Blood samples for toxicological analysis were taken on admission, after 4, 8 and 12 hours. Toxicological analysis consisted of measurements of ethanol, acetaldehyde, methanol and acetone concentrations. The ethanol co"]

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