Search for: [Abstract = "Endothelial cells are characterized by intense metabolic activity. They participate in maintaining the body's homeostasis, including blood pressure control \(vasoconstriction and vasodilation\), oxygen concentration, blood coagulation regulation, energy balance control, and also in the process of angiogenesis. The main factors causing dysfunction and, as a result, vascular endothelial diseases are a poorly balanced diet and an incorrect lifestyle. Dysfunction of endothelium is accompanied by an imbalance between the vasodilators and vasoconstrictors synthesis. As a result, there is an increased synthesis of reactive nitrogen and oxygen species, activation of the inflammatory reaction, damage, and aging of cells. The factor causing the development of the pathological condition within the cardiovascular system is chronic inflammation due to the lack of an effective mechanism of resolution of inflammation and the process of tissue healing. Polyunsaturated fatty acids and their derivatives are pharmacologically active lipid mediators, which play an essential role in the body's physiological and pathological processes. The active lipid mediators of n\-3 and n\-6 polyunsaturated fatty acids, belong to the compounds involved in the resolution of inflammation. Supplementation with n\-3 fatty acids has an antioxidant and protective effect on the cardiovascular system thanks to the biosynthes"]

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