Search for: [Abstract = "Due to the widespread therapeutic application of antibiotics and progressive ‘chemicalization’ of the environment, the influence of partial elimination of the natural gut flora on contact sensitivity \(CS\) response in mice was studied. Modification of natural gut flora by broad spectrum antibiotic leads to inhibition of CS reaction. Suppression of CS reaction is due to induction of different types of regulatory cells in axillary and inguinal lymph node \(ALN\), spleen \(SPL\), mesenteric lymph node \(MLN\) and Payer patch \(PP\). Identified cells have suppressive activity in vivo.Induction of regulatory cells is associated with a shift of bacteria profile towards anti\-inflammatory strains, which produce SCFA and induce Treg cells. Immunosuppressive potential of gut flora was confirmed by fecal microbiota transplantation experiments. In summary, the results suggest that manipulation of gut flora composition is a powerful tool to modulate systemic immune response."]

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