Search for: [Abstract = "Disertation presents findings of pharmacological in vitro and in vivo studies evaluating functional effects of newly synthesized two series of long\-chain azinesulfonamide\-arylpiperazine derivatives. The other aim of this study was the attempt to clarify mechanism of their potential psychotropic activity. Aripiprazole was used as a reference the 3rd generation antipsychotic drug.In radioligand studies in vitro, carried out for 12 compounds belonging to the series of quinoline\- or isoquinoline\-sulfonamide derivatives of monochlorophenylpiperazine and 14 quinoline\- or isoquinoline\-sulfonamide derivatives of 2,3\-dichlorophenylpiperazine, monoaminergic receptor binding profile has been determined. Of the analogs tested, five compounds were selected from each series \(respectively, PZ\-395, PZ\-397, PZ\-493, PZ\-510, PZ\-511 and PZ\-380, PZ\-387, PZ\-508, PZ\-549, PZ\-599\), for which intrinsic activity has been evaluated in vitro and\/or in vivo to specific receptors \(presynaptic 5\-HT1A receptor  body temperature in mice, postsynaptic 5\-HT1A receptor  lower lip retraction test in rats, 5\-HT2A receptor  head\-twitch responses in mice, D2 receptor  climbing in mice, determining a level of cAMP in vitro in CHO cells expressing the human 5\-HT1A or 5\-HT7 receptor\). Compounds with the most favorable functional profile was further investigated, the aim was to determine their psychotropic activity in"]

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