Search for: [Abstract = "Disertation presents findings of pharmacological in vitro and in vivo studies evaluating functional effects of EMD 386088, a 5\-HT6 receptor ligand, after its acute, subchronic and chronic administration. The other aim of this study was the attempt to clarify mechanism of its potential antidepressant and anxiolytic activity in rats.Executed radioligand studies confirmed a high affinity of EMD 386088 toward 5\-HT6 receptors, expanded data on its receptor profile and selectivity. Functional in vitro studies provided the first direct body of evidence for partial agonist activity of EMD 386088 toward 5\-HT6 receptors and despite of its moderate affinity for 5\-HT3 receptors, for lack of antagonist 5\-HT3 activity. The obtained in vivo findings demonstrate that EMD 386088 produces specific effects characteristic of antidepressants after its acute, subchronic and chronic treatment in the forced swim test in rats and in bulbectomized rats. Its antidepressant\-like activity is directly connected with stimulation of 5\-HT6 receptors, and indirectly with activation of dopaminergic system via D1 and D2 receptors as well as with inhibition of dopamine reuptake. A potential antidepressant effect of EMD 386088 does not seem to be connected with serotonergic andZał. nr 1 do § 2 zarządzenia nr 45Rektora UJ z 12 czerwca 2006 rokunoradrenergic innervations. EMD 386088 administered jointly with imiprami"]

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