Search for: [Abstract = "Despite intense studies, prognosis and early diagnosis of SAP is still a challenge. In every day practice, careful observation of a patient and frequent evaluation by attending physician is necessary. Nowadays, it is routinely supported by advanced, wider accessible imaging, application of prognostic scales \(Ranson, Glasgow, APACHE II\) and measurement of certain laboratory biomarkers, mainly associated with inflammation \(CRP, procalcitonin\). The aim of the PhD thesis was the estimation of diagnostic usefulness of new biomarkers in prediction of severe and complicated course of AP. Analysis of correlations between concentrations of NGAL \(in serum and urine\), Ang\-2 and selected microRNAs and the severity of AP in early phase of the disease was performed. Author tried to answer the following questions\:1. Do concentrations of Ang\-2 and NGAL in serum as well as NGAL in urine increase in the early phase of AP\?2. What is the dynamics of changes in concentrations of the4analyzed markers in patients with severe form of AP comparing to other early markers of inflammation\?3. Do concentrations of Ang\-2, uNGAL and sNGAL allow early prognosis of severity of AP and early diagnosis of organ complications in the course of this disease\? Particularly is determination of uNGAL and Ang\-2 useful in recognition of AKI as a complication of AP\?4. Is determination of microRNA useful in early evaluation of AP severity\?"]

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