Search for: [Abstract = "Depression is one of the most common psychiatric disorders among thegeneral population. It is often characterized by a recurrent or chronic course, and itimposesa considerable burden on both the patients and their families. Depressive disordersoften diminish patients’ ability to get good education and find gainful employment,leading to significant impairment. According to the WHO rapport published in 2001depression in the course of bipolar disorder will be the leading cause of disabilityworldwide in 2020.Approximately 30% of patients diagnosed with depression do not achieveimprovement following the initial antidepressant trial. About half of this subgroupwill not respond adequately to the second antidepressant trial either. High ratio ofrecurrence \(80\-85%\) contributes to unsatisfactory effectiveness of the availabletreatments. There are two groups of patients\: one in which many differentantidepressive drugs were admitted and there were no satisfactory improvement ofmental state and the second group where the treatment brings improvement but aftera longer period of time.Low remission rates among substantial proportion of chronicallydepressed patients contribute to a number of adversities, such as\: higher psychiatrichospitalization ratio, higher burden of medical condition, and trend towardsworsening of depressive symptoms over. Those patients have shorter survival time,their fam"]
