Search for: [Abstract = "Cow's milk is one of the most common causes of food allergies among children, and caseins constitute 80% of its proteins. There is a group of patients in whom allergic reaction to cow's milk is delayed, possibly cell\-mediated. Recent discoveries have shown that excessive cellular response can be inhibited using specific suppressive exosomes with miRNA\-150. The aim of the research was to describe the mechanism of delayed\-type hypersensitivity \(DTH\) reaction to casein in mice and to evaluate the potential therapeutic application of casein\-specific suppressive exosomes. In the present study, it was shown that DTH reaction to casein in mice is mediated by CD4 \+ Th1 lymphocytes and macrophages. The suppressive properties of casein\-specific exosomes were confirmed in adoptive transfer in vitro and in a mouse model of DTH to casein in vivo. The strongest suppression effect was obtained with the oral route of exosomes administration. doktorat"]

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