Search for: [Abstract = "Concentrated ethanol is one of many xenobiotics which cause injury to upper gastrointestinal tract mucosa but the mechanism of this action is still incompletely established. In cases of acute alcohol poisoning the direct necrotizing effect of consumed alcohol on the mucous membrane epithelium as well as the vascular reaction caused by vasoactive mediators \(histamine, leukotrienes\) released from mastocytes by the action of alcohol seems to be of principle significance. In the course of chronic alcohol consumption, in addition to lesions arising on acute intoxication, induction of an inflammatory reaction occurs in the form of mucosal inflammatory infiltrations particularly in the gastric antrum. The inflammatory process of the gastric mucosa has various activity and intensification and clinical signs. The recession of symptoms of acute poisoning or withdrawal syndrome does not stay in direct relation to the resolution or intensity of gastrointestinal tract disorders. The assessment of gastrointestinal injury in alcohol dependent patients is difficult due to the coincidence of different exogenic factors which cause gastric mucosal injury such as\: smoking, Helicobacter pylori infection, malnutrition, abuse of medication or the coincidence of other alcohol related organ injury, especially of the liver and pancreas. In these cases the connection of an etiological factor to a certai"]
