Search for: [Abstract = "Chronic aspirin intake after successful desensitization is an effective and safe treatment method for patients with nonsteroidal antiinflammatory drugs exacerbated respiratory disease \(N\-ERD\). Aspirin provocation test remains a reliable diagnostic method of aspirin hypersensitivity. Objectives\: 1. The assessment of the impact of chronic aspirin therapy on selected clinical, biochemical and radiological factors in patients with N\-ERD. 2. An attempt to create an artificial neural network \(ANN\) that would allow a noninvasive and rapid diagnosis of N\-ERD. It was shown that chronic aspirin intake leads to a decrease in periostin concentration and eosinophil count in induced sputum. It was also demonstrated that chronic aspirin intake does not affect the levels of pro\- and anti\-inflammatory eicosanoids produced locally \(ie, in induced sputum supernatant and nasal lavage\) and systemically \(ie, in urine\). The ANN can be used to predict the diagnosis of N\-ERD in patients with asthma. The sensitivity of the ANN for the prediction of N\-ERD was 94% and the specificity was 73%."]
