Search for: [Abstract = "Calcific aortic stenosis \(AS\) is the most common form of valvular heart disease in adults. The early lesions in aortic valve leaflets are similar to those observed in atherosclerosis. It has been shown that AS is a prothrombotic state, characterized by increased thrombin formation and platelet activation, which is accompanied by systemic inflammation. Despite extensive research efforts, there is no effective treatment of the progression of AS. The presence of symptoms including heart failure, angina, dizziness and syncope in a patient with AS requires aortic valve replacement, because delay of the therapy worsens the prognosis. The management of asymptomatic AS patients is controversial. Several studies performed over the past decades have aimed to established the optimal treatment in this group of patients.In 2013, Natorska et al. have reported that hypofibrinolysis is more common in AS patients than in controls. Moreover, it is known that exercise can induce a prothrombotic state. It has been suggested that beneficial effects of physical activity on the risk of cardiovasculardisease may result at least in part from increased fibrinolysis. To our knowledge, there have been no published studies on the effect of exercise on blood coagulation and fibrinolysis in AS patients. The present study was performed to evaluate potential differences in the haemostatic response to exercise"]

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