Search for: [Abstract = "C57BL\/6, apoE knock\-out, p47phox knock\-out\). Vascular effects of leptin, resistin and ghrelin on vascular wall tension, as well as, on nitric oxide dependent endothelial function were analysed using isometric tension studies in vitro \(organ bath technique\). Our data demonstrate that leptin and resistin induce significant endothelial dysfunction in mice by direct NADPH oxidase activation and increased superoxide production. Additionally, leptin has been shown to activate endothelial nitric oxide synthase in thoracic aorta in mice. In the present study we show, that ghrelin is able to inhibit directly vascular superoxide production and NADPH oxidase activity in SHR as well as abolish the difference between SHR and WKY. The antioxidant activities of ghrelin were also proved in human vessels in which greater vasorelaxation dependent on NO and induced by acetylcholine was observed. Inhibition of vascular NADPH oxidase and superoxide production by ghrelin may indicate its potential antiatherosclerotic properties, however, this suggestion requires further investigation."]

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