Search for: [Abstract = "Bronchopulmonary dysplasia is a chronic disorder of respiratory function, defined as oxygen dependence of child sustained above 28 days old and need to rescue breathing in 36 revised week of life. The cause of development includes exposure to high concentrations of oxygen during oxygen therapy, ventilation and invalid construction and functions of surfactant proteins. One of the four surfactant proteins is SP\-B, a fundamental element to preserve the integrity of the lung and epithelial cells forming surfactant phospholipids layers structures. Probably it also prevents damage to the lungs caused by oxygen and regulates the immune response in the airways. Mutations in protein transporting ABCA3 gene is another genetic factor combined with a shortage of surfactant. Protein ABCA3 is necessary for proper development of the lamellar bodies which are involved in storing and secreting of surfactant components. The purpose of the dissertation was to verify hypotheses about the absence of differences between the prevalence of genetic variants within protein surfactant B and protein transporting ABCA3 genes between sample and control 3 groups. The test group accounted for 82 children with bronchopulmonary dysplasia. The control group consisted of 250 random infants. Both populations were tested for the presence of gene variants of the 10 exons of the SP\-B gene sequence. Four changes were"]

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