Search for: [Abstract = "Background Endothelial inflammatory activation is associated with profound impairment in vasodilator endothelial function. The aim of the study was to analyze the impact of short\-term anti\-inflammatory therapy with high dose statin and cycklooxygenase\-2 \(COX\-2\) inhibitor on endothelial function in patients with non ST segment elevation Acute Coronary Syndromes \- NSTE ACS. Methods In 30 pts with NSTE ACS and elevated C reactive protein level endothelial function was assessed by coronary Acetylcholine \(Ach\) test within non\-culprit vessel. Quantitative coronary angiography was done at baseline and after maximum dose of Ach. Vessel response was calculated as a percent change of mean lumen diameter \(% change of Mean Lumen Diameter \(LD\)\). Then pts were randomized to three groups\: A \(n=11\) placebo, B \(n=11\) 80 mg atorvastatin, C \(n=8\) 80 mg atorvastatin and 25 mg rofecoxib. After 7 days of therapy control test was done within the same indicatory segments. Recovery of endothelial function was calculated as difference \(delta\) in % changes of Mean LD between day 1 and day 7. Results At day 1 significant decrease in Mean LD between baseline and the highest dose of Ach was observed in all groups\: \-20 % \(group A\), \-25 % \(B\) and \-26 % \(C\). After 7 days of therapy these changes averaged \-21 % \(A\), \-15 % \(B\) and \-10 % \(C\). Differences between day 1 and day 7 were \-1% \(A\), \+10 % \(B\), \+16 % in C"]

Number of results: 1