Search for: [Abstract = "Background\: Vitamin D deficiency is an epidemiological problem considered as a risk factor for diseases. Vitamin D deficiency may be a factor involved in of Hashimoto's thyroiditis \(HT\)pathogenesis. Study Aim \: assessment of vitamin D impact on the course of HT in patients of Holy Cross Region.Material and Methods\: We examined 310 adults\: 155\- HT, 155 healthy ones. The HT was divided into subgroups\: H – hypothyroid, treated with l\-thyroxine \(N = 110\), E – euthyroid, not treated \(N = 45\). In 71 HT’s patients it was rated the mutation in HLA\-DRB1.Results\: The median of 25OHD3 in HT was significantly lower – 23,20 ng\/mL \(18,60\-29,00\) than in the control – 25,60 ng\/mL \(21,01\-31,35\) \(p <0,001\), but not in the E subgroup \- 28,7 \(21,4\-33,2\). There was a negative correlation of 25OHD3 with duration of the HT \(p <0,001\), but no with time <2 years. In the H \- the median of 25OHD3 was significantly lower – 21.50 ng\/ml \(17.80\-27.30\) than in the E – 28,7 ng\/mL \(21,40\-33,02\) \(p <0.001 \). In patients \(\-\)a\/TPO\/a\/Tg, the median of 25OHD3 was significantly higher – 32 \(25,63\-37,68\)\/28.7 \(23,20\-32,70\) ng\/ml, than in \(\+\)\/TPO\/a\/Tg – 22,1 \(18,1\-28,4\)\/20.2\(15,4\-23,6\) ng\/ml \(p <0,001\). The allele DRB1\*11\:04 was significantly more frequent and twice increased the risk of HT\; DRB1\*15\:01 was significantly lower and twice reduced the risk. The proper concentration of 25OHD3 was more frequent at the presen"]

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