Search for: [Abstract = "Background\: Psoriasis is one of the most common skin diseases occurring in about 0.6\-4.8% of the adult population in the world . The core feature of the disease is increased number of mitotic figures in the basal lamina of the epidermis and accelerated abnormal maturation of keratinocytes, coexistent with inflammatory cell infiltrates containing lymphocytes, monocytes and granulocytes in the dermis – which actively penetrate the epidermis. Enhanced localized inflammatory reaction may be a reflection of the systemic effect through release of various inflammation mediators such as proinflammatory cytokines. Based upon epidemiological studies some investigators demonstrate that psoriatic patients are significantly more frequently affected by cardiovascular disease. Psoriasis is most frequently associated with arterial hypertension, heart valve disease and atherosclerosis. The reasons for this relationship may be the inflammatory character of psoriasis and abnormal microcirculation on the one hand, and concomitant endocrine disorders, type 2 diabetes and oxidative stress on the other hand. Aim\: To evaluate cardiovascular disorders in psoriatic patients. To define a correlation between the clinical manifestations of psoriasis \(clinical type of psoriasis, severity of skin lesions, duration of the disease and recent eruption, frequency and reason of exacerbation\), serum levels of some cytokines \(with known stimulating and inhibiting effects in psoriasis such as TNFα, IL\-6, IL\-4, IL\-10, and as yet unclear effects such as IL\-12, IL\-18\) and cardiovascular disorders based upon echocardiography and arterial compliance. Material and Methods\: The study population consist of 40 men with psoriasis, aged 25\-55 years\: 20 men at low cardiovascular risk \(total risk cardiovascular death over 10 years according to the SCORE < 2%\) no hyperlipidemia, no hypertension and non\-smoking \(Gpsa1=8 men with psoriatic arthritis, Gps2=12 men with psoriasis vulgaris\) and 20 men at intermediate and high risk of cardiovascular death SCORE > 5% with various risk factors \(hypertension, hyperlipidemia, smoking\) \(GPSA3=9 men with psoriatic arthritis, GPS4=11 men with psoriasis vulgaris\). Age\-matched 40 men without psoriasis divided into two subgroups\:c5,C6 \(20 men each\) by cardiovascular risk level similar to psoriatic patients serve as the controls. Cardiovascular disorders have been evaluated by echocardiography \(left ventricular systolic and diastolic function, left ventricular mass index \(LVMI\), atrial dimension \(PL\), ascending aorta width \(AoD\), aortic and mitral insufficiency \(AR, MR\)\) using the Hewlett Packard Sonos 2000 machine. Arterial compliance have been measured from pulse wave velocity using the Complior ® device. Cytokine levels have been measured with the immunoenzymatic methods \(R\&D England\). Statistical analysis was performed with Statistica 6.0. Results\: Both groups ie. psoriatic patients \(37,4 ± 2,0 yrs.\) and controls \(36,4 ± 2,0 yrs.\) had no age difference \(p> 0,05\). Mean body mass index was higher for psoriatic patients \(26,2 ± 0,6 kg\/m²\) than for controls \(23.95 ± 0.65 kg\/m², p< 0.001\). Heart rate, systolic and diastolic blood pressures were similar in both groups. Cholesterol and LDL cholesterol levels in psoriatic patients were higher than in controls. Mean concentration of white blood cells was on the same level in both psoriatic and control groups but percentage of lymphocytes in blood smear in psoriatic group was lower than in control group. Additionaly in psoriatic vulgaris group independently on SCORE rate the percentage of basophiles in blood smear was higher than in control group with SCORE rate below 2% and in psoriatic arthritis group with SCORE rate over 5%. When PWV values were compared patients with SCORE rate below 2% and psoriatic arthritis \( mean PWV = 9,38±0,54m\/s\) and psoriasis vulgaris \(mean PWV = 9,0±0,44 m\/s\) had higher values than controls with the same SCORE rate \( mean PWV = 7,6±0,34 m\/s\), p< 0,001."]

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