Search for: [Abstract = "Background\: Diabetes mellitus is a widespread disease with anessential impact on morbidity of contemporary societies. The qualityof life and the life span of the patients depend on the occurrence of chronic diabetic complications. There are many data indicating, that oxidative stress, caused by the enhancement of the reactive oxygen species formation or impairment of the mechanisms neutralizing effects of the uncontrolled oxidation process lies behind generation and further progression of chronic diabetic complications. In diabetes, there is no evidence on the increased superoxide anion formation, as itis in inflammatory state or reperfusion of ischemic tissues. Formation of reactive oxygen species in diabetes is disseminated and is linked to a “dormant inflammatory state”, which presence is marked by anincrease in basic level of C\-reactive protein. Among factors linking oxidative stress with generation of chronic complications of diabetes there are\: chemical action of the high glucose concentrations on cellular metabolism, protein glycation, formation of the advanced glycated end products \(AGEs\), activation of transcription factors and activation of protein kinase C. Search for interrelation between oxidative stress in diabetes and generation of diabetes chronic complications is still an important research challenge.Objective\: The study was aim to evaluate oxidative stress par"]

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